Aman Chauhan, MD, discusses combining intratumoral Seneca Valley virus (SVV-001) with ipilimumab and nivolumab in neuroendocrine cancer.
|Videos|November 14, 2016
HER2+ Early-Stage Breast Cancer with Ruth O'Regan, MD Case 2
HER2+ Early-Stage Breast Cancer with Ruth O'Regan, MD
Advertisement
Case Scenario 2:
- This is a 33-year old pre-menopausal woman who, after palpating a mass in her left breast, was referred for a mammogram by her primary care physician. Family history includes a sister who died of breast cancer at age 43 years.
- Her mammogram revealed a spiculated mass in the upper outer quadrant of the left breast. Targeted ultrasound showed a 2.6 x 3.4 x 2.1 cm irregular mass with an indistinct margin. Prominent appearing right axillary lymph nodes.
- Pathology: core biopsy revealed an invasive ductal carcinoma, poorly differentiated, lymphovascular invasion present. The tumor sample was mammaglobin-positive, ER/PR-negative, and HER2 3+ by IHC. Axillary ultrasound with fine-needle aspiration which was also positive for nodal involvement.
- The case was presented at the breast cancer multidisciplinary tumor board. The team recommended neoadjuvant therapy before surgery.
Advertisement
Related to this article
Claire K. Mulvey, MD, explains how patient-reported outcomes and QOL assessments reveal NEN symptom burden and help guide treatment.
Nikolaos Trikalinos, MD, reviews CABINET data showing cabozantinib improved PFS in functional and nonfunctional NETs without added grade 3 toxicity.
Liver transplant led to durable survival in unresectable NET liver metastases; tumor burden predicted outcomes, and recurrence was common but treatable.
Mark A. Lewis, MD, explains how oral cabozantinib reduces time toxicity for patients with previously treated, well-differentiated neuroendocrine tumors.
Erica S. Alexander, MD, highlights endovascular approaches to venous occlusion, including stenting and thrombolysis, for select patients with NETs.
Amr Mohamed, MD, reviews zocilurtatug pelitecan phase 1/2 data in platinum-refractory extrapulmonary neuroendocrine carcinoma.
In a phase 1 trial, a single intratumoral injection of oncolytic virus SVV-001 with ipilimumab and nivolumab was safe in high-grade neuroendocrine cancers.
Advertisement
Advertisement
Trending on Targeted Onc
1
FDA Approves Amivantamab and Hyaluronidase for Recurrent/Metastatic HNSCC
2
Zocilurtatug Pelitecan Shows Activity in epNEC Across DLL3 Expression Levels
3
LITESPARK-011 Raises Questions About RCC Treatment Sequencing
4
Dr Mohamed on Zocilurtatug Pelitecan for Refractory Extrapulmonary NEC
5