High-Risk Primary Myelofibrosis

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High-Risk Primary Myelofibrosis

  • A 53-year-old woman complains of increasing abdominal discomfort, early satiety, and 15-lb weight loss over the past 5 months
  • Abdominal examination reveals splenomegaly, palpable 8 cm. below the costal margin without hepatomegaly
  • CT scans of the chest, abdomen, and pelvis reveal moderate mediastinal lymphadenopathy and splenomegaly
  • Laboratory values:
    • WBC: 1.9 x 103cells/mm3
    • ANC: 1.4 x 103cells/mm3
    • Hb: 9.1 gm/dl
    • Platelets: 77,000 cells/mm3
  • Bone marrow biopsy:
    • MF-3
    • CD34+/CD117+ immunostaining demonstrated 1.2% blasts
    • JAK2-V617Fmutation
  • Diagnosis: primary myelofibrosis
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Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
Andrew Kuykendall, MD, an expert on polycythemia vera
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