May 18, 2017


January 2017

  • A 74-year old female with a history of HCV-infection
  • Prior treatment with interferon, achieving sustained virologic response
  • Had recurrence of HCV
  • CT scan showed a 6.5-cm single liver mass with arterial enhancement, venous phase washout, and main portal vein invasion
  • ECOG=1
  • Child-Pugh A
  • Therapy was initiated with sorafenib at 400 BID
  • Patient experienced grade 3 hand-foot skin reaction; dose reduction to 400 QD
  • Patient experienced grade 3 diarrhea; dose reduction to 400 QOD

April 2017

  • Follow-up scans show radiographic progression with lung metastases