Initial Strategies in Advanced HCC: Case 2 - Episode 2
Richard Finn, MD: In this case, the patient does have some cancer-related symptoms: fatigue and weight loss. She is otherwise fairly well compensated based on her blood work and exam. She would be considered Child-Pugh A. But, on imaging, she has invasion of the vasculature and also enlarged lymph nodes, which are suggestive of metastatic disease, not to mention the lesions in her chest as well.
So, this is a patient who is presenting with advanced liver cancer who is well compensated, and by the Barcelona criteria, this would be considered BCLC-C liver cancer. The question then becomes, what is the next step in managing this patient? In this case scenario, the patient is referred for liver biopsythough it is not required—and that shows poorly differentiated histology, which is a negative prognostic factor in the setting of a patient who already has portal vein invasion and metastatic disease.
This is a good candidate for systemic treatment. Currently, the only agent that has been shown to improve survival for advanced liver cancer and is approved for that indication is sorafenib. Sorafenib is a multikinase inhibitor that hits the VEGF receptor, as well as other intracellular proteins felt to be important in oncogenesis. That, for many years, has been shown repeatedly to have a survival advantage in patients with Barcelona Class-C liver cancer who are well compensated or Child-Pugh A.
This patient has advanced liver cancer, and we had discussed that the treatment options are really going to be sorafenib or consideration for a clinical research study. This patient has a history of some noncompliance with her medications and, therefore, is not felt to be a good candidate for a clinical study. She is started on a standard of care, sorafenib at 400 mg/twice a day orally.
Transcript edited for clarity.