A Case of Estrogen-Driven Metastatic Breast Cancer

A 65-Year-Old Woman With Metastatic ER+/PR+ Breast Cancer

December 2013

• A 65-year-old woman was examined by her gynecologist after discovering a right-sided lump in her upper inner breast; she reported feeling exhausted lately, requiring frequent rest
• PE showed a grape-sized right palpable mass at 3 o’clock
• Diagnostic ultrasound showed a spiculated and hypoechoic mass measuring 26 x 23 x 21 mm; imaging in the left breast was unremarkable
• Core biopsy showed high-grade infiltrating ductal carcinoma
  • Hormone receptor status: ER+/ PR+
  • HER2,IHC 1+
• She underwent lumpectomy and axillary lymph node dissection that revealed a 2.3-cm infiltrating ductal carcinoma, 4 of 12 nodes were positive for disease
• CT of the chest, abdomen, and pelvis showed that the disease had spread to her bones and biopsy confirmed metastatic disease
• ECOG 1
• She was started on ribociclib + fulvestrant