Georgina V. Long, BSc, PhD, MBBS, discusses the response rates in the CheckMate 067 trial, which evaluated the combination of ipilimumab and nivolumab in patients with advanced melanoma.
Georgina V. Long, BSc, PhD, MBBS, co-medical director of Melanoma Institute Australia (MIA), chair of Melanoma Medical Oncology and Translational Research at MIA and Royal North Shore Hospital, University of Sydney, discusses the response rates in the CheckMate 067 trial (NCT01844505), which evaluated the combination of ipilimumab (Yervoy) and nivolumab (Opdivo) in patients with advanced melanoma.
Of the patients who had a complete response (CR) with the combination, 80% remained in CR at 5 years. Similarly, 79% who were in CR on nivolumab plus placebo had not progressed at the 5-year mark. Long says they investigated the 20% of patients who had progressed after a CR and saw features associated with overall prognosis.
Features associated with poor prognosis were patients with M1C melanoma, which is disease that has spread to other organ sites; patients with non-cutaneous melanoma; or patients with acral lentiginous melanoma. These patients were more likely to progress after CR, although it was a small number of patients.
The investigators are also looking at whether stopping therapy early or the use of corticosteroids for toxicity affected whether patients progressed after having a CR. Long believes there may be a relationship with the use of corticosteroids and/or the duration of treatment and how well patients maintain CR.
Similar Efficacy in Melanoma Shown in Indirect Comparison of PD-1/LAG3 vs PD-1/CTLA-4
July 16th 2024During a Case-Based Roundtable® event, Michael A. Postow, MD, discussed an indirect treatment comparison of nivolumab plus relatlimab vs nivolumab plus ipilimumab in patients with advanced melanoma in the first article of a 2-part series.
Read More
Examining Breast Cancer Recurrence Detection Methods in a Community Oncology Setting
July 12th 2024In an interview with Targeted Oncology, Ali Duffens, MD, discussed findings from a study which investigated detecting breast cancer recurrence among women treated at Kaiser Permanente Northern California.
Read More