Dual HER2-Targeted Neoadjuvant Therapy for BC

October 9, 2017

A 53-year-old woman was referred to a breast surgeon after finding a mass in her left breast
- PMH: unremarkable
- FH: no history of cancer in first-degree relatives
- PE: revealed a 6 X 5-cm, non-fixed mass in the left inferior breast without skin changes or nipple discharge, and palpable lymphadenopathy in the left axilla
- ROS: clear
Mammogram confirmed a left-sided, poorly defined spiculated mass. Ultrasound shows a 5.3-cm solid mass and enlargement of 2 left axillary nodes with thickened cortex
Pathology results:
- Core needle biopsy from the breast mass confirmed grade 3 invasive ductal carcinoma
  - ER,PR,HER2IHC 3+
  - FISH,HER2copy number, 15;HER2:CEP17 ratio, 7
- Fine-needle aspiration of one left axillary lymph nodes was positive for carcinoma
Staging: T2bN1M0