ADCs improved on chemotherapy-based regimens in PD-L1–negative and EGFR-mutated NSCLC, while chemotherapy plus pembrolizumab and pumitamig plus docetaxel showed activity in PD-L1–high and post-chemoimmunotherapy disease.
|Videos|November 12, 2016
Sonja Althammer Discusses Biomarkers for Durvalumab in Lung Cancer
Author(s)Sonja Althammer, PhD
Sonja Althammer, PhD, Team Leader Bioinformatics at Definiens, discusses a study looking to define a subgroup of patients with non–small cell lung cancer who respond best to treatment with the PD-L1 inhibitor durvalumab.
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Sonja Althammer, PhD, Team Leader Bioinformatics at Definiens, discusses a study looking to define a subgroup of patients with nonsmall cell lung cancer (NSCLC) who respond best to treatment with the PD-L1 inhibitor durvalumab.
Findings from the analysis were presented at the Society for Immunotherapy of Cancer (SITC) 31st Annual Meeting & Associated Programs. Overall, the combination of CD8+ and PD-L1+ densities correlated with response and improved overall survival with durvalumab.
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