Ghassan K. Abou-Alfa, MD:This patient has metastatic disease now to the lung. By all means, this is a time where the interventional radiologist should sit with the oncologist at the tumor board or pick up the phone and say, “Maybe it’s time to start talking about systemic therapy.” And this patient by all means should go, again, on sorafenib as standard of care as a first-line of treatment or on a clinical trial if readily available at that time.
This patient appears to be that their bilirubin, which was totally normal at about 1.0, jumped about 1.8, which put them in a category of a high bilirubin that continues to 2.1. Their Child-Pugh score now is right on the edge between A and B, maybe a B7 if, let’s say, the albumen is a little bit low as well. In that scenario, sorafenib is still appropriate, but there are data already published. The first author, Miller, fromJCOa few years ago showed that for a bilirubin between 1.5 and 3 of the upper limit of normal, half the dose of the sorafenib will be appropriate. And this is where maybe a patient like this should be monitored very closely with bilirubin and other things, and still be given sorafenib with close monitoring. Close monitoring means that patients will be seen probably on a weekly basis, have their bilirubin checked, and be taught about any symptoms that will probably reflect on increased bilirubin like, for example, jaundice, change in the color of urine, yellow eyes, etc.
When sorafenib was first approved, there was a certain excitement that this was a pilljust give it to the patient and then check on them at a certain later point in time. A close follow-up is so critical for patients on sorafenib and probably is going to be the same for regorafenib patients. You’ve got to make sure that you check on the patients on a regular basis. When we start therapy, I personally will probably give a call to the patient within 3 to 4 days. Anybody in the office can do that—the doctor or the nurse—checking to see how things are because hand-foot syndrome might be evolving at that time. And, within a week’s time, patients should be seen in the clinic as well. It should not be underestimated how critical it is to closely follow up with those patients to avoid them from going to grade 3 toxicity, where options for them might be limited. And so, maximizing on the potential for the therapy by close monitoring and avoiding the worsening of the side effects is critical and of prime importance.
Transcript edited for clarity.
May 2015
February 2017
Hope Beyond Surgery: Optimizing Care for Cholangiocarcinoma
February 15th 2024In an interview for Cholangiocarcinoma Awareness Day, Domenech Asbun, MD, discussed how the management of cholangiocarcinoma continues to evolve and addressed unmet needs in early detection and systemic therapy.
Read More
Durvalumab/Bevacizumab/TACE Significantly Extends Survival in HCC
February 6th 2024In an interview with Targeted Oncology, Bruno Sangro, MD, PhD, discussed the potential durvalumab, bevacizumab, and TACE has to set a new standard-of-care among patients with unresectable hepatocellular carcinoma.
Read More