Recurrent HR+ Breast Cancer - Episode 4
Joyce O’Shaughnessy, MD:There has been great progress in estrogen receptor [ER­]-positive, HER2-negative metastatic breast cancer recently. The CDK4/6 inhibitors are really a very important new therapeutic opportunity for patients because in the first-line setting, we’re having median progression-free survivals of over 2 years. Now we have the introduction of our first PI3K inhibitor in this population, albeit just for the 35% to 40% of women whose breast cancers have a somatic mutation in PI3K.
I am really looking forward to triplet trials in the first-line setting with endocrine therapy and aromatase inhibitor or fulvestrant with a CDK4/6 inhibitor combined with either alpelisib or everolimus. I think we really want to block the PI3 kinase pathway and the CDK4/6 with excellent inhibition of the estrogen receptor to really get dramatic and even more prolonged progression-free survival [PFS] for patients. There are these triplet studies ongoing right now, and I really look forward to those data in the future to see if we can truly make breast cancer into a chronic disease with extremely long progression-free survival in the first-line setting.
Transcript edited for clarity.
A 58-Year-Old Woman With Recurrent HR+ Breast Cancer