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Opinion|Videos|June 27, 2024

Best Candidates for HER2-Directed ADCs in HR+/HER2-Low Metastatic Breast Cancer

Author(s)Aditya Bardia, MD, MPH, Laura Huppert, MD

Experts on breast cancer describe the best candidates for HER2-directed antibody-drug conjugates in HR+/HER2-low metastatic breast cancer, highlighting the role of trastuzumab deruxtecan in later lines of therapy.

Episodes in this series

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 1 Treatment Sequencing and Unmet Needs in HR+/HER2-Low Metastatic Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 2 DESTINY-Breast04: Trastuzumab Deruxtecan in HR+/HER2-Low Metastatic Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 3 Best Candidates for HER2-Directed ADCs in HR+/HER2-Low Metastatic Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 4 Insights on T-DXd and Emerging Research on ADCs in HR+/HER2-Low Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 5 Emerging Pathways and Role of TROP2-Directed ADCs in HR+/HER2- mBC

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 6 TROPION-Breast01: Dato-DXd in HR+/HER2- Metastatic Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 7 TROPiCS-02: Sacituzumab Govitecan in HR+/HER2- Metastatic or Locally Recurrent Breast Cancer

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 8 Clinical Utilization of TROP2-Directed Antibody-Drug Conjugates

Aditya Bardia, MD, MPH, FASCO, and Laura Huppert, MD, experts on breast cancer

EP. 9 Future of TROP2- and HER2-Directed ADCs in Breast Cancer

Video content above is prompted by the following questions:

Which patients are most suitable for a HER2-directed antibody-drug conjugate (ADC) in HR+/HER2-low metastatic breast cancer?
Would you consider trastuzumab deruxtecan for second-line therapy or as a later line?

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