Arvind Dasari, MD, MS, reviews key advances in neuroendocrine tumors, including new PRRT options, alpha emitters, cabozantinib, and clinical trials.
|Videos|July 16, 2018
The Clinical Management of Primary Myelofibrosis
The Clinical Management of Primary Myelofibrosis
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March 2017
- A 67-year old woman presents to her primary care physician with complaints of fatigue, abdominal fullness, night sweats, and 17-lb weight loss over the past 6 months.
- PMH includes hypertension, controlled on enalapril 10 mg
- Abdominal examination reveals spleen palpable 7 cm below the costal margin
- Lab values:
- HGB: 9.2 gm/dl
- Platelets: 189 x 109/L
- WBC: 19 x 109/L
- Bone Marrow Biopsy:
- MF-3
- CD34+/CD117+ immunostaining demonstrated 1.2% blasts
- JAK-V617F mutation
- Diagnosis: Primary myelofibrosis
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Arvind N. Dasari, MD, MS, reviews a year in neuroendocrine tumors marked by expanding radioligand options, improved classification, and disappointing combination therapies.
Older age, kidney disease, and prior irradiation were linked to elevated myeloid neoplasm risk after lutetium Lu 177 dotatate in a real-world NET analysis.
Aman Chauhan, MD, discusses combining intratumoral Seneca Valley virus (SVV-001) with ipilimumab and nivolumab in neuroendocrine cancer.
Claire K. Mulvey, MD, explains how patient-reported outcomes and QOL assessments reveal NEN symptom burden and help guide treatment.
Nikolaos Trikalinos, MD, reviews CABINET data showing cabozantinib improved PFS in functional and nonfunctional NETs without added grade 3 toxicity.
Liver transplant led to durable survival in unresectable NET liver metastases; tumor burden predicted outcomes, and recurrence was common but treatable.
Mark A. Lewis, MD, explains how oral cabozantinib reduces time toxicity for patients with previously treated, well-differentiated neuroendocrine tumors.
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