Metastatic Melanoma with Jason Luke, MD and Jeffrey Weber, MD, PhD: Case 2 - Episode 4
What can be done to help predict which patients might experience durable responses to targeted therapy, like Sarah's?
Factors that might predict the benefit over a long period of time for targeted therapy are currently under development. The research space, what we have available now really, are clinical factors such as ageyounger being more likely to respond and do better over time—low LDH, sites of disease being less than three and not liver metastases as well as not brain metastases obviously. Those are really the predictors that we have to try to identify patients right now.
CASE: Metastatic Melanoma
Sarah is a 50-year-old Caucasian postal worker who presented to her primary care physician with multiple, skin-colored nodules and palpable lymph nodes. .
The patient was started on the combination of dabrafenib and trametinib. She experienced a durable complete response and has remained on therapy for 36 months.