Patient Profile: A 43-Year-Old Man with RAI-R-DTC

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EP: 1.Patient Profile: A 43-Year-Old Man with RAI-R-DTC

EP: 2.Overview of Radioiodine-Refractory Differentiated Thyroid Cancer (RAI-R-DTC)

EP: 3.Treatment Landscape for Patients with Advanced RAI-R-DTC

EP: 4.Standard-of-Care Treatment for Patients with Advanced RAI-R-DTC

EP: 5.Treatment Selection for Patients With RAI-R-DTC

EP: 6.Lenvatinib Treatment Considerations in RAI-R-DTC

EP: 7.Data on Age and Randomization of Dose in Patients with RAI-R-DTC

EP: 8.Treatment Sequencing and Advice for Community Oncologists Treating RAI-R-DTC

Case: A 43-Year-Old Man with RAI-R-DTC

Initial presentation and initial treatment:

• A 43-year-old man presents with fatigue, neck pain and dysphagia and was diagnosed with papillary thyroid carcinoma 10 years ago
• Following a total thyroidectomy, he underwent multiple rounds of radioactive ablation therapy.
• Initial response was positive with undetectable thyroid globulin levels and negative imaging
• PMH: Hyperlipidemia; Hypertension; Diabetes (controlled with medications)
• SH: lives with his wife and 2 teenage children; non-smoker and drinks alcohol occasionally
• PE: appears fatigued with a palpable thyroid nodule in the left lobe
• Neck examination: palpable mass in the left neck, and cervical lymphadenopathy

Clinical workup

• Labs: WNL
• Neck ultrasound: Identifies a large, irregular mass in the left thyroid bed with invasion into surrounding structures.
• CT of the neck and chest revealed neck mass along with multiple pulmonary nodules, largest 2cm x 1.5cm
• TSH: Within normal limits
• Thyroglobulin levels: Markedly elevated
• Radioactive iodine scan: Confirms radioiodine refractory disease with widespread involvement of cervical lymph nodes and distant metastases.
• Needle biopsy was performed which confirmed Papillary thyroid cancer. Next-generation sequencing was negative for mutations, rearrangements

Subsequent treatment and follow-up

• Lenvatinib 24mg po qd was initiated

This is a video synopsis/summary of a Case-Based Peer Perspectives featuring Marcia S. Brose, MD, PhD.

Brose presents a case of a 43-year-old man diagnosed with papillary thyroid cancer 10 years prior. The patient had undergone a total thyroidectomy and multiple rounds of radioactive iodine therapy. He presented with fatigue, neck pain, difficulty swallowing, and a palpable mass in the left neck. Imaging revealed a neck mass invading surrounding structures and multiple pulmonary nodules. A radioactive iodine uptake scan confirmed disease refractory to radioactive iodine. Next-generation sequencing was negative for mutations and rearrangements. The patient started on lenvatinib at 24 mg.

Brose discusses the appropriateness of lenvatinib treatment, noting its superior response rate and progression-free survival rate when compared with sorafenib, as demonstrated in a phase 2 head-to-head study. She also emphasizes the importance of starting lenvatinib at the full 24 mg dose, as supported by dose-finding studies showing improved outcomes without increased grade 3 adverse events or detriment to overall functioning.

Video synopsis is AI-generated and reviewed by Targeted Oncology™ editorial staff.