Sandip P. Patel, MD, reviews the case of a 60-year-old woman with early-stage non–small cell lung cancer (NSCLC).
Case: A 60-Year-Old Woman with Early-Stage Non–Small Cell Lung Cancer
Initial presentation and Clinical Workup
This is a video synopsis/summary of a Case-Based Peer Perspectives featuring Sandip P. Patel, MD.
This case involves a 60-year-old Caucasian female with a 45 pack-year smoking history who presented with a nonproductive cough and was found to have a 5.5-cm right upper lobe lung mass on imaging. Biopsy showed TTF-1–positive adenocarcinoma consistent with non-small cell lung cancer (NSCLC). Staging workup was negative for lymph node involvement or distant metastases. The patient underwent right upper lobectomy with clear margins. Pathology showed a 5.5-cm tumor, pathologic T3N0M0 (stage IIA) lung adenocarcinoma. Molecular testing revealed an EGFR exon 19 deletion and 40% PD-L1 expression.
Postoperatively, the patient completed adjuvant cisplatin and pemetrexed therapy. Due to the EGFR mutation, she was started on osimertinib. Twenty months after initiating osimertinib, she developed headaches and worsening fatigue. Imaging showed 3 new liver lesions concerning for metastases and 1 new potential central nervous system lesion.
Video synopsis is AI-generated and reviewed by Targeted Oncology™ editorial staff.