|Videos|July 16, 2018

Diagnosis and Treatment of Myelofibrosis

June 2016

A 72-year old male presents to his primary care physician with fatigue, abdominal pain lasting 3 months, and night sweats
PMH includes depression and gout
Physical Exam: BP, 155/85; spleen palpable 6 cm below costal margin
Laboratory values:
- Hb= 9.8 g/L
- HCT= 38%
- WBC= 22.3 x10⁹/L
- Platelets= 255 x10⁹/L
Bone marrow biopsy:
- Megakaryocytic proliferation and atypia with evidence of reticulin fibrosis
Blood smear showed leukoerythroblastosis
Genetic testing showsJAK2 V617Fmutation
Diagnosis: Primary myelofibrosis

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