Underlying Treatment of Myeloproliferative Neoplasms

January 2016

• A 59-year-old male presents to his physician with symptoms of fatigue and abdominal pain lasting 3 months; he also reports increased bruising
  • Physical Exam: Spleen is palpable, 6 cm. below left costal margin
• CBC with differential
  • RBC; 3.20 x 10¹²/L
  • HGB; 9.3 g/dL
  • HCT; 34%
  • MCV; 93.1 fL
  • WBC; 12.1 x 10⁹/L
  • PLT; 247 x 10⁹/L
  • PB BLASTS; 0%
• Genetic testing showsJAK2V617Fmutation
• Bone marrow biopsy showed megakaryocyte proliferation and atypia with evidence of reticulin fibrosis