Prithviraj Bose, MD:We have a 58-year-old woman at The University of Texas MD Anderson Cancer Center presenting with some abdominal pain, dizziness, and headaches; blood pressure is a little elevated, just mildly; a slightly enlarged spleen. She’s never had a clot. Hemoglobin count is elevated at 17.1 g/dL. The white blood cell count is elevated as well, 13.2. The EPO [erythropoietin] level is conspicuously low. Bone marrow shows erythroid hyperplasia, and she has aJAK2mutation.
So here we have a lady who pretty clearly has PV [polycythemia vera]. You see that her hemoglobin count is higher than the WHO [World Health Organization] thresholds. She has a low EPO level. She has aJAK2V617Fmutation. She has a bone marrow that’s typical with the erythroid hyperplasia. She has pancytosis with her white blood cell count being elevated as well, so it’s a pretty clear-cut case of PV.
Transcript edited for clarity.
Case: 58-Year-Old Woman Diagnosed With Polycythemia Vera