Haris Ali, MD, discusses research supporting the use of ruxolitinib for the treatment of myelofibrosis.
Haris Ali, MD, a hematologist/oncologist and associate clinical professor, Department of Hematology & Hematopoietic Cell Transplantation at the City of Hope Comprehensive Cancer Center, discusses research supporting the use of ruxolitinib (Jakafi) for the treatment of myelofibrosis.
According to Ali, COMFORT-1 (NCT00952289) and COMFORT-2 (NCT00934544), showed that ruxolitinib showed good responses when compared to best available treatment or other supportive treatments. It was also shown beneficial for the treatment of polycythemia vera.
Ruxolitinib was recently approved for the treatment of graft versus host disease (GvHD) and has shown promise in chronic GvHD. According to Ali, this is due to the unique mechanism of improving inflammation, which is the main driver in patients with myelofibrosis, other myeloproliferative neoplasms, and GvHD.
Rossetti Reviews Myelofibrosis Risk Stratification and Outcome Data for Pacritinib
July 17th 2024During a Case-Based Roundtable® event, James M. Rossetti, DO, discussed the role of risk scoring and stratification tools and treatment for a patient with declining hemoglobin and platelet counts due to primary myelofibrosis.
Read More
Phase 3 VERIFY Trial Investigates Rusfertide’s Potential in Polycythemia Vera
July 16th 2024In an interview, Aniket Bankar, MD, discussed the background, design, and goals of the phase 3 VERIFY trial of the hepcidin mimetic rusfertide for the treatment of patients with polycythemia vera.
Read More
Ruxolitinib Treatment in Myelofibrosis Still Effective, Regardless of Anemia
June 21st 2024New or worsening anemia did not appear to reduce the clinical benefit of ruxolitinib in myelofibrosis patients, and the median overall survival was similar between patients with and without new or worsening anemia.
Read More