Roundtable Roundup April: Renal Cell Carcinoma

CASE SUMMARY

• An African American woman aged 59 years presented with a left renal mass.
• She underwent left radical nephrectomy, which revealed clear cell RCC.
• Nine months later, she developed nodules in both lungs, mediastinum (35 × 38 mm), and retroperitoneal lymph nodes.
• Lung biopsy confirmed stage IV RCC with clear cell histology.
• Karnofsky performance status: 90%
• Hemoglobin: 11.1 g/dL
• Corrected calcium, neutrophils, and platelets: within normal limits

POLLING QUESTION

A decision was made to initiate systemic therapy. What frontline therapy are you most likely to choose for this patient?