Targeted Oncology reviews trending news online for the week of October 30, 2020, including recent news from the FDA, updates in oncology, and new information regarding COVID-19.
This week, the FDA granted approval to the FoundationOne Liquid biopsy assay as a companion diagnostic for several indications.
The FDA also granted an Orphan Drug designation for soft tissue sarcoma, a Priority Review designation for PD-L1-high advanced or metastatic non–small cell lung cancer (NSCLC), as well as a Priority Review for HER2-positive metastatic gastric/gastroesophageal junction adenocarcinoma.
Adjuvant Osimertinib Induces Promising CNS FDS in Early Stage EGFR-Mutant NSCLC
In an interview with Targeted Oncology, Masahiro Tsuboi, MD, discussed the findings from the ADAURA study, which explored the role of osimertinib (Tagrisso) as treatment of patients with early-stage EGFR-mutant NSCLC following a complete tumor resection.
Novel IDH1 Inhibitor Demonstrates Safety and Preliminary Efficacy in R/R AML
The IDH1 inhibitor olutasidenib showed a favorable safety profile in patients with relapsed/refractory acute myeloid leukemia treated in a phase 1/2 clinical trial.
PSMA Sparks Interest for Detection and Targeting in Men With Prostate Cancer
In an interview with Targeted Oncology, Naomi Haas, MD, discussed the role of PSMA in the treatment landscape of prostate cancer and highlighted the key findings from the phase 1 chimeric antigen receptor T-cell trial in metastatic castration resistance prostate cancer.
Adagrasib Demonstrates Significant Disease Control in KRAS G12C+ Non-Small Cell Lung Cancer
Adagrasib (MRTX849) demonstrated promising antitumor activity as monotherapy in patients with previously treated KRAS G12C–mutant NSCLC.
High-Risk MCL Population Represents Unmet Need in Treatment Landscape
The treatment landscape of mantle cell lymphoma has been enriched with the development of several targeted therapies, but patients considered to have high-risk disease tend to have a worse prognosis, despite the latest development in the field.
Immunotherapy Combinations Improve Survival in Advanced Renal Cell Carcinoma
Bradley McGregor, MD, discusses the current treatment landscape for patients with advanced or metastatic renal cell carcinoma, which has significantly evolved over the last few years.
Expanding Options for Treatment of CLL Using BTK Inhibitors
Jennifer R. Brown, MD, PhD, and Alan Skarbnik, MD, describe the rationale for treating chronic lymphocytic leukemia with BTK inhibition, and explore current trends in data that impact treatment selection.
How to Leverage Real-World Data as COVID-19 Transforms Clinical Trials
Due to efforts to reduce exposure to the coronavirus, oncology patient volumes initially decreased, treatment regimens were disrupted or altered, and new cancer diagnoses also slowed. This affected not only patient care, but also clinical trials.
Epcoritamab Delivers Durable Responses in Anthracycline-Ineligible LBCL
December 12th 2024Fixed-duration, subcutaneous epcoritamab-bysp achieved durable responses with a manageable safety profile in older patients with newly diagnosed large B-cell lymphoma who are not candidates for anthracycline-based therapy.
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Navigating ESR1 Mutations in HR-Positive Breast Cancer With Dr Wander
October 31st 2024In this episode of Targeted Talks, Seth Wander, MD, PhD, discusses the clinical importance of ESR1 mutations in HR-positive metastatic breast cancer and how these mutations influence treatment approaches.
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