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Opinion|Videos|July 17, 2024

SEQUOIA Arm D Study: Zanubrutinib plus Venetoclax in Treatment-Naive CLL/SLL with del(17p) and/or TP53 Mutations

Author(s)Mazyar Shadman, MD, MPH

A blood cancer specialist discusses the latest data from the SEQUOIA Arm D trial investigating zanubrutinib plus venetoclax in treatment-naïve patients with CLL and del(17p) and/or TP53 mutations.

Episodes in this series

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 1 Clinical Approaches in High-Risk Patients with CLL/SLL

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 2 SEQUOIA Arm D Study: Zanubrutinib plus Venetoclax in Treatment-Naive CLL/SLL with del(17p) and/or TP53 Mutations

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 3 Updates from the CAPTIVATE Study Evaluating Ibrutinib + Venetoclax in TN CLL/SLL

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 4 Future Implications of Combination Regimens and Treatment Duration in CLL/SLL

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 5 Examining Toxicity Management of BTK Inhibitors for CLL/SLL

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 6 Treatment Paradigms for Clinical Progression of CLL/SLL Beyond Initial Therapies

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 7 Perspectives on Indirect Comparisons of BTK Inhibitors for R/R CLL/SLL

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 8 Additional Data and Key Takeaways in CLL/SLL from EHA 2024

Mazyar Shadman, MD, MPH, an expert on CLL

EP. 9 Future Outlooks in the Treatment of CLL/SLL

Video content above is prompted by the following questions:

Please briefly discuss the latest results from the SEQUOIA Arm D trial, evaluating zanubrutinib plus venetoclax in treatment-naïve patients with CLL and del(17p) and/or TP53 mutations.
- How does the efficacy of zanubrutinib + venetoclax compare to SOCs in high-risk patients with del(17p) and/or TP53 mutations in CLL/SLL?

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