Evolving Landscape of First-Line Therapies in Metastatic RCC: Cabozantinib-Based Approaches
Rana McKay, MD, discusses how the first-line treatment landscape for metastatic renal cell carcinoma has evolved, comparing efficacy and safety profiles of various treatment combinations, considering patient-specific factors and disease characteristics in treatment selection, addressing the management of adverse events, and exploring ongoing challenges and future directions in therapy.
Panelists discuss how the efficacy and safety profiles of various treatment options for intermediate/poor-risk metastatic renal cell carcinoma compare, including cabozantinib monotherapy, nivolumab plus cabozantinib combination, nivolumab plus ipilimumab combination, and other immune checkpoint inhibitor plus tyrosine kinase inhibitor combinations.
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EP. 3: Navigating ICI Plus TKI Combinations for First-Line mRCC: Key Factors in Decision-Making
October 7th 2024Panelists discuss how they approach selecting among various immune checkpoint inhibitor (ICI) plus tyrosine kinase inhibitor (TKI) combinations for first-line treatment of metastatic renal cell carcinoma, considering key factors that influence their decision-making process and drawing insights from recent clinical trials such as CheckMate 9ER, KEYNOTE-426, and CLEAR.
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Panelists discuss how specific disease characteristics, such as tumor burden, metastatic sites, and risk stratification, most strongly influence their decision-making process when choosing between immune checkpoint inhibitor plus tyrosine kinase inhibitor (ICI plus TKI) regimens and dual immune checkpoint inhibitor (ICI plus ICI) combinations for treating metastatic renal cell carcinoma.
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