Lyudmila Bazhenova, MD, discusses the FDA’s expanded approval of taletrectinib for ROS1-positive non–small cell lung cancer.
|Videos|April 19, 2021
A 68-Year-Old Woman with ALK+ Non–Small Cell Lung Cancer
Author(s)Karen Reckamp, MD
Karen Reckamp, MD, comments on the management and treatment of a 68-year-old woman with ALK+ NSCLC, as well as data demonstrated in the ALTA-1L trial, use of brigatinib, and her own clinical experiences.
Advertisement
Case: A 68-Year-Old Woman with ALK+ Non–Small Cell Lung Cancer
Initial presentation
- A 68-year-old woman presented with fatigue, wheezing and decreased appetite
- PMH: unremarkable
- PE: wheezing on auscultation; ECOS PS 1
Clinical Workup
- Labs: WNL
- Chest x-ray showed a left lower lobe mass
- Chest/abdomen/pelvic CT scan confirmed a 6.8-cm left lower lobe lung mass and a suspicious liver lesion
- PET scan showed activity in the left lower lobe mass and liver
- MRI of the brain showed several subcentimeter lesions without edema
- Bronchoscopy with transbronchial biopsy of the left lower lobe mass confirmed lung adenocarcinoma
- Molecular testing: NGS revealed EML4/ALK fusion+, EGFR-, ROS1-, BRAF-, KRAS-, NTRK-, MET-, RET-, PD-L1 0% by IHC
- Staging: IVB adenocarcinoma
Treatment
- Patient was started on brigatinib 90 mg qDay for 7 days; well tolerated; dose was increased to 180 mg qDay
Advertisement
Related to this article
During a live event, Mary Jo Fidler, MD, and participants discussed how an intermediate-risk regimen, insurance resistance, and limited experience with trilaciclib shape neutropenia prevention in extensive-stage disease.
For Hispanic Heritage Month, Narjust Florez, MD, discusses lung cancer risk, biomarker testing, and trial access in Hispanic and Latinx patients.
A phase 2 trial is planned for an allogeneic CAR T-cell product in patients with lung or breast cancer with brain metastases.
Advertisement
Advertisement
Trending on Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways
1
Dostarlimab Receives FDA Approval for MSI-H/dMMR Locally Advanced Rectal Cancer
2
FDA Accepts NDA for UGN-103 in Recurrent LG-IR-NMIBC
3
Dr Bazhenova on the Updated FDA Label for Taletrectinib in ROS1+ NSCLC
4
2026 AACR Report Highlights Advances and New Directions in Cancer Treatment
5