NEWS
CONFERENCES
MEDIA
PUBLICATIONS
CASE-BASED ROUNDTABLE
PARTNERS
RESOURCES
SUBSCRIBE

Your AI-Trained Oncology Knowledge Connection!

Opinion|Videos|March 26, 2024

Determining and Addressing Ruxolitinib Failure in Myelofibrosis

Author(s)Stephen Oh, MD, PhD

An expert on myelofibrosis discusses how to determine whether a patient is experiencing ruxolitinib failure or disease progression and provides insights on when to intervene or change therapy.

Episodes in this series

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 1 Patient Profile: A 63-Year-Old Man with Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 2 Determining and Addressing Ruxolitinib Failure in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 3 Treatment Sequencing in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 4 Monitoring Therapeutic Response in Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 5 Pacritinib for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 6 Balancing Toxicity Concerns with Achieving Adequate Response in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 7 Emerging JAK Inhibitors for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 8 Perspectives on the Future on Myelofibrosis Treatment

Case: A 63-Year-Old Man with Myelofibrosis

Clinical Presentation:

A 63-year-old man recently diagnosed with primary MF and initiated on 10 mg BID ruxolitinib.
PMH: type 2 diabetes, hypercholesteremia, and hypertension, squamous cell carcinoma (SCC)

Follow up and Clinical Workup at 3 Months:

Exam: night sweats improved.
Labs: Hb 7.8 g/dL; Plt 80 x 109/L (previously 135k) stabilized.
Some spleen reduction.
Patient receives ~1 unit RBC per month.

Follow up and Clinical Workup at 6 Months:

Patient reports complaints of fatigue and abdominal pain.
Labs: Plt 55 x 109/L; Hgb 6.8 g/dL
Patient now receives 2 units RBC per month.
Experienced recurrence of SCC.

Newsletter

Stay up to date on practice-changing data in community practice.

Related Content

CAR T in Heme Malignancies: Patient Outcomes Inform Care Needs

ByAndrea Eleazar, MHS

January 7th 2026

The Top 5 Blood Cancer Advancements in 2025

December 27th 2025

Real-World Data Link Higher Hemoglobin to Improved Survival in MDS

BySabrina Serani,Ira Zackon, MD

December 16th 2025

Imetelstat Improves Outcomes in Heavily Transfusion-Dependent MDS

ByAndrew M. Brunner, MD

December 15th 2025

MMUD Grafts Yield Similar Survival Outcomes Despite Lower HLA Match Levels

ByRoman Fabbricatore

December 15th 2025

Latest CME

42nd Annual CFS: Chemotherapy Foundation Symposium®: Innovative Cancer Therapy for Tomorrow

42nd Annual CFS: Chemotherapy Foundation Symposium®: Innovative Cancer Therapy for Tomorrow

Benjamin P. Levy, MD; John O. Mascarenhas, MD; Tiffany A. Traina, MD, FASCO; Cathy Eng, MD, FACP, FASCO; John P. Leonard, MD

Community Oncology Connections™: Beyond Primary End Points—Digging Into Randomized and Real-World Data to Guide Challenging Treatment Decisions in HR+/HER2− Metastatic Breast Cancer | Washington State Medical Oncology Society

Community Oncology Connections™: Beyond Primary End Points—Digging Into Randomized and Real-World Data to Guide Challenging Treatment Decisions in HR+/HER2− Metastatic Breast Cancer | Washington State Medical Oncology Society

Marla D. Lipsyc-Sharf, MD; Ashley Frith, MD

The Inaugural Hawaii Breast Cancer: A Multidisciplinary Case-Based Conference

The Inaugural Hawaii Breast Cancer: A Multidisciplinary Case-Based Conference

Hope S. Rugo, MD, FASCO; Naoto T. Ueno, MD, PhD

43rd Annual Miami Breast Cancer Conference®

In-Person Event

43rd Annual Miami Breast Cancer Conference®

March 5-8, 2026

Medical Crossfire®: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2– Breast Cancer

Medical Crossfire®: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2– Breast Cancer

Joyce O’Shaughnessy, MD; William J. Gradishar, MD, FASCO, FACP; Heather McArthur, MD, MPH

Updates and Innovations in Nonopioid Pain Management Strategies for Breast Cancer Patients Postsurgical Intervention

Updates and Innovations in Nonopioid Pain Management Strategies for Breast Cancer Patients Postsurgical Intervention

Patrick I. Borgen, MD; Joshua Feinberg, MD; Gary Schwartz, MD, FASA

Shaping Surgical Pathways: Revolutionizing Breast Cancer Care With Genetic Testing and Targeted Treatment

Shaping Surgical Pathways: Revolutionizing Breast Cancer Care With Genetic Testing and Targeted Treatment

Patrick I. Borgen, MD; E. Shelley Hwang, MD, MPH; Mark E. Robson, MD

Community Practice Connections™: Navigating the Impact of HER2, HER3 and TROP2 from Early Stage to Advanced Breast Cancer Care

Community Practice Connections™: Navigating the Impact of HER2, HER3 and TROP2 from Early Stage to Advanced Breast Cancer Care

Hope S. Rugo, MD, FASCO; Sara Hurvitz, MD, FACP; Jennifer Litton, MD, MHCM; Heather McArthur, MD, MPH

Community Practice Connections™: Exploring Emerging Next-Generation Endocrine Therapies in ER+/HER2- Breast Cancer – Evaluating the Potential of Future of Treatment

Community Practice Connections™: Exploring Emerging Next-Generation Endocrine Therapies in ER+/HER2- Breast Cancer – Evaluating the Potential of Future of Treatment

Heather McArthur, MD, MPH; Komal Jhaveri, MD, FACP; Sara Tolaney, MD, MPH; Seth A. Wander, MD, PhD

Community Practice Connections™: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2- Breast Cancer

Community Practice Connections™: Translating Evidence to Clinical Practice in Early-Stage HR+, HER2- Breast Cancer

Joyce O’Shaughnessy, MD; William Gradishar, MD, FASCO, FACP; Heather McArthur, MD, MPH; Eleni Anastasia Tousimis, MD, MBA, FACS

Community Practice Connections™: Optimizing Treatment Outcomes and Preserving Fertility in Premenopausal HR+ Breast Cancer

Community Practice Connections™: Optimizing Treatment Outcomes and Preserving Fertility in Premenopausal HR+ Breast Cancer

Rebecca Shatsky, MD; Kelly McCann, MD, PhD; Michelle L. Taylor, ANP-BC

Innovations in HR+/HER2– Metastatic Breast Cancer: Advancing Care Through PROTAC ER Degradation

Innovations in HR+/HER2– Metastatic Breast Cancer: Advancing Care Through PROTAC ER Degradation

Rita Nanda, MD; William Gradishar, MD, FASCO, FACP; Komal Jhaveri, MD, FACP; Kevin Kalinsky, MD, MS

Clinical Case Vignette Series™: 42nd Annual Miami Breast Cancer Conference®

Clinical Case Vignette Series™: 42nd Annual Miami Breast Cancer Conference®

Reshma Jagsi, MD, DPhil; Kevin Kalinsky, MD, MS; Hope S. Rugo, MD, FASCO; Alastair Thompson, MD, MBChB, BSc (Hons), FRCS (Ed), FACS

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Breast Cancer Tumor Board®: Advancing Care in Metastatic Breast Cancer - The Evolving Role of Antibody-Drug Conjugates

Breast Cancer Tumor Board®: Advancing Care in Metastatic Breast Cancer - The Evolving Role of Antibody-Drug Conjugates

Aditya Bardia, MD, MPH, FASCO; Joyce O’Shaughnessy, MD; Hope S. Rugo, MD; Paolo Tarantino, MD

Trending on Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways

NCCN Updates Breast Cancer Guidelines: Sacituzumab Govitecan for 1L TNBC

FDA Accepts BLA for Ivonescimab in Pretreated EGFR-Mutated NSCLC

FDA Grants FTD to GPRC5D Bispecific LBL-034 for R/R Multiple Myeloma

Multiomic Real-World Data Predict Outcomes in Metastatic Breast Cancer

Onvansertib Triplet Shows Dose-Dependent Frontline Benefit in RAS-Mutant Metastatic CRC