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Opinion|Videos|March 26, 2024

Balancing Toxicity Concerns with Achieving Adequate Response in Myelofibrosis

Author(s)Stephen Oh, MD, PhD

An overview of how toxicity concerns are balanced with the goal of achieving adequate response in patients with myelofibrosis who receive sequential therapies such as JAK inhibitors.

Episodes in this series

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 1 Patient Profile: A 63-Year-Old Man with Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 2 Determining and Addressing Ruxolitinib Failure in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 3 Treatment Sequencing in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 4 Monitoring Therapeutic Response in Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 5 Pacritinib for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 6 Balancing Toxicity Concerns with Achieving Adequate Response in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 7 Emerging JAK Inhibitors for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 8 Perspectives on the Future on Myelofibrosis Treatment

Case: A 63-Year-Old Man with Myelofibrosis

Clinical Presentation:

A 63-year-old man recently diagnosed with primary MF and initiated on 10 mg BID ruxolitinib.
PMH: type 2 diabetes, hypercholesteremia, and hypertension, squamous cell carcinoma (SCC)

Follow up and Clinical Workup at 3 Months:

Exam: night sweats improved.
Labs: Hb 7.8 g/dL; Plt 80 x 109/L (previously 135k) stabilized.
Some spleen reduction.
Patient receives ~1 unit RBC per month.

Follow up and Clinical Workup at 6 Months:

Patient reports complaints of fatigue and abdominal pain.
Labs: Plt 55 x 109/L; Hgb 6.8 g/dL
Patient now receives 2 units RBC per month.
Experienced recurrence of SCC.

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