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Opinion|Videos|July 12, 2024

AGAVE-201 Trial Review

Author(s)Corey S. Cutler, MD, MPH, FRCPC, Hannah Choe, MD

A hematologist provides an overview of the AGAVE-201 trial investigating axatilimab in patients with chronic graft-vs-host disease.

Episodes in this series

Corey Cutler, MD, MPH, and Hannah Choe, MD, experts on GVHD

EP. 1 Overview of Acute/Chronic GVHD

Corey Cutler, MD, MPH, and Hannah Choe, MD, experts on GVHD

EP. 2 Review of MOA and Effectiveness of Current Treatments

Corey Cutler, MD, MPH, an expert on GVHD

EP. 3 Axatilimab, Anti-CSF1R, a New Treatment Class

Hannah Choe, MD, an expert on GVHD

EP. 4 Unmet Needs in the Management of cGVHD

Corey Cutler, MD, MPH, and Hannah Choe, MD, experts on GVHD

EP. 5 AGAVE-201 Trial Review

Corey Cutler, MD, MPH, and Hannah Choe, MD, experts on GVHD

EP. 6 Where Does Axatilimab Fit in the Treatment Lineup?

Corey Cutler, MD, MPH, and Hannah Choe, MD, experts on GVHD

EP. 7 Next Steps in the Development of Axatilimab

Video content above is prompted by the following questions:

Please provide an overview of the AGAVE-201 trial, including its design, patient population, and key endpoints.
- What were the primary and secondary endpoints of the AGAVE-201 trial, and how were they assessed?
- How did the trial evaluate the efficacy, safety, and tolerability of different dosing regimens of axatilimab in patients with recurrent or refractory active chronic GVHD?

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