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Opinion|Videos|March 26, 2024

Patient Profile: A 63-Year-Old Man with Myelofibrosis

Author(s)Stephen Oh, MD, PhD

Stephen T. Oh, MD, PhD, presents the case of a 63-year-old man previously diagnosed and treated with primary myelofibrosis.

Episodes in this series

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 1 Patient Profile: A 63-Year-Old Man with Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 2 Determining and Addressing Ruxolitinib Failure in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 3 Treatment Sequencing in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 4 Monitoring Therapeutic Response in Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 5 Pacritinib for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 6 Balancing Toxicity Concerns with Achieving Adequate Response in Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 7 Emerging JAK Inhibitors for Patients With Myelofibrosis

Stephen T. Oh, MD, PhD, an expert on myelofibrosis

EP. 8 Perspectives on the Future on Myelofibrosis Treatment

Case: A 63-Year-Old Man with Myelofibrosis

Clinical Presentation:

A 63-year-old man recently diagnosed with primary MF and initiated on 10 mg BID ruxolitinib.
PMH: type 2 diabetes, hypercholesteremia, and hypertension, squamous cell carcinoma (SCC)

Follow up and Clinical Workup at 3 Months:

Exam: night sweats improved.
Labs: Hb 7.8 g/dL; Plt 80 x 109/L (previously 135k) stabilized.
Some spleen reduction.
Patient receives ~1 unit RBC per month.

Follow up and Clinical Workup at 6 Months:

Patient reports complaints of fatigue and abdominal pain.
Labs: Plt 55 x 109/L; Hgb 6.8 g/dL
Patient now receives 2 units RBC per month.
Experienced recurrence of SCC.

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