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Commentary|Videos|December 12, 2025

Odronextamab Plus CHOP Shows Early Success in Untreated DLBCL

Fact checked by: Paige Britt

The Olympia-3 study explores odronextamab as a promising chemo-free treatment for untreated diffuse B-cell lymphoma patients.

In an interview with Targeted Oncology, Jean-Marie Michot, MD, Institute Gustave Roussy, discussed the details of the Olympia-3 (NCT06091865) study for patients with previously untreated diffuse large B-cell lymphoma.

The Olympia-3 study is examining the replacement of rituximab (Rituxan) with odronextamab plus chemotherapy. Early results for odronextamab plus CHOP showed that the objective response rate was 78% with the weekly 80 mg dose, rising to 100% with the 160 mg weekly dose. Similarly, complete response rates sharply differed, registering 44% and 100% for the respective 80 mg and 160 mg doses.

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