Safety of Venetoclax and Ibrutinib in CLL

Paolo Ghia, MD, PhD, of the Università Vita-Salute San Raffaele, discusses the safety profile of ibrutinib (Imbruvica) plus venetoclax (Venclexta) in patients with chronic lymphocytic leukemia (CLL).

According to Ghia, no out of the ordinary safety signals were reported. Neutropenia was the most common adverse event (AE), occurring in 33% of patients.

Additionally, there was also some mild grade diarrhea, according to Ghia. Most AEs observed were grade 1 and 2. Of the 156 patients, only 3 had to discontinue treatment due to toxicity.