Follicular Lymphoma: Treating Early Progressors

November 20, 2019

Follicular Lymphoma: Treating Early Progressors


Case: A 62-Year-Old Male with Follicular Lymphoma

H & P:

  • A 62-year-old man presents with lower abdominal discomfort and rapid weight loss over last 3 months
  • PMH: Hypertension managed by statin
  • PE: palpable inguinal lymphadenopathy

Diagnostic Work-Up

  • Hematologic results
    • ANC: 1200 /µL
    • Platelets: 89,000 /µL
    • β2-microglobulin: 3.5 mg/L
    • Serum LDH: 230 IU/L
  • Imaging: PET/CT reveals axillary and bilateral inguinal lymphadenopathy; 5 masses (~3cm each)
  • Biopsy: FL, grade 2
  • FLIPI status: High-risk
  • Ann Arbor: Stage IV
  • ECOG PS: 1

Treatment

  • Patient treated with obinutuzumab + bendamustine
    • Completed 6 cycles, achieved CR