The Future of Upper Gastric Cancer Treatment


David Zhen, MD, provides advice to oncologists treating patients with upper gastric cancer and offers closing thoughts on the future treatment landscape, highlighting challenges and unmet needs.

Case: A 60-Year-Old Man with Stage IV Gastric Adenocarcinoma

Clinical Presentation:

  • A 60-year-old man with abrupt 10-pound weight loss, dyspepsia, bloating after meals, and loss of appetite, and all symptoms worsening over the past three months.
  • PMH and FHx: Overweight and HTN. Patients father deceased at age 50 due to gastric cancer.

Initial Clinical Workup and Diagnosis:

  • EGD showed 2 cm protruding mass in the body of the stomach
    • No Ulcerations
    • Biopsy showed poorly differentiated adenocarcinoma
  • Stage IV adenocarcinoma
  • Molecular Testing: HER2/neu –; MMRp/MSS, PD-L1 CPS 5%
  • CT of abdomen and chest reveal a gastric polypoid mass and thickening; No ascites; 2 lesions in the left lower lobe.
  • Lung Biopsy: metastatic adenocarcinoma consistent with gastric primary
  • PET/CT confirmed metastatic disease

Current Treatments:

  • Patient was initiated on FOLFOX +nivolumab
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