Feature|Articles|February 20, 2026

Understanding the Biological and Social Complexities of Triple-Negative Breast Cancer

How ancestry, neighborhood stress and chemo side effects shape TNBC outcomes—and why immunotherapy and tailored care can narrow survival gaps.

In the landscape of oncology, triple-negative breast cancer (TNBC) remains one of the most challenging subtypes to treat due to its aggressive nature and the lack of traditional hormonal targets. However, for Samilia Obeng-Gyasi, MD, MPH, a surgical oncology specialist at The James, The Ohio State University Comprehensive Cancer Center, the challenge is not just biological; it is deeply rooted in ancestry, social environment, and patient experience.