Colin G. Evans, PhD | Authors

Articles

Preventing and Treating Bone Metastases in mCRPC

April 19, 2016

Bone metastases in metastatic castration-resistant prostate cancer (mCRPC) can invade a range of sites in the skeleton where they precipitate a spectrum of pathological processes that increase morbidity, negatively affect quality of life, and decrease survival.

First-in-Class Cancer Stemness Inhibitor Shows Promising Results in Advanced Colorectal Cancer

January 27, 2016

The latest results from an open-label, phase Ib study of the STAT3 inhibitor BBI-608 (napabucasin) with a standard chemotherapy (FOLFIRI with or without bevacizumab) in the treatment of advanced colorectal cancer, have been presented at the ASCO 2016 Gastrointestinal Symposium. Evidence of antitumor activity and a favorable safety profile were seen in phase I studies.