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Head & Neck Cancers | Clinical
HPV16+ HNSCC Response to PDS0101 Plus Pembrolizumab in VERSATILE-002
June 08, 2022
In CPI-naïve, HPV16-positive, CPS-positive patients, PDS0101 plus pembrolizumab exhibits preliminary evidence of clinical benefit in a majority of patients with an acceptable safety profile and allows continued dosing of pembrolizumab.
Positive Responses Shown With Rivoceranib in Patients With Adenoid Cystic Carcinoma
June 08, 2022
Rivoceranib showed promising responses in regard to objective response rate and disease control rate when used in patients with recurrent or metastatic adenoid cystic carcinoma.
Avasopasem Treatment Lead to Fewer Severe Oral Mucositis in Patients Receiving Chemoradiotherapy for Advanced Head and Neck Cancer
June 04, 2022
Reductions in severe oral mucositis across all intensity-modulated radiotherapy landmarks was observed with avasopasem treatment in patients with locally advanced, nonmetastatic head and neck cancer.
FDA Grants Fast Track Status to PDS0101 Plus Pembrolizumab for Recurrent/Metastatic HPV16+ HNSCC
June 02, 2022
A fast track designation has been granted by the FDA to the combination of PDS0101 and pembrolizumab, an investigational regimen for the treatment of patients with recurrent or metastatic HPV16-positive head and neck squamous cell carcinoma.
FDA Does Not Approve Frontline Toripalimab +/- Chemo for Advanced/Metastatic Nasopharyngeal Carcinoma
May 02, 2022
A complete response letter from the FDA has been issued regarding the biologics license application for toripalimab with or without chemotherapy for the treatment of advanced recurrent or metastatic nasopharyngeal carcinoma.
Head and Neck Cancer Treatment Evolution Leads the Way for Future Developments
April 29, 2022
For Head and Neck Cancer Awareness Month, Robert L. Ferris, MD, PhD, FACS, elaborated on the significant progress in the head and neck cancer space, as well as potentially practice-changing results that will come with emerging agents In an interview with Targeted Oncology™.
FDA Grants Fast Tracks SQZ-PBMC-HPV for HPV16+ Advanced/Metastatic Solid Tumors
April 28, 2022
The FDA has granted fast track designation to SQZ-PBMC-HPV for the treatment of patient with HPV16-positive advanced or metastatic solids tumors, according to an announcement by SQZ Biotechnologies.
Pepinemab/Pembrolizumab May Be Active in Recurrent/Metastatic Head and Neck Cancer
April 22, 2022
According to results from the phase 1b portion of the study KEYNOTE-B84 study, pepinemab plus pembrolizumab achieved complete responses in 2 of the first 3 patients with head and neck cancers enrolled.
Tislelizumab Holds PFS Benefit After 15 Months in Recurrent/Metastatic Nasopharyngeal Carcinoma
April 20, 2022
Updated results from the RATIONALE-309 study show that tislelizumab continues to prolong PFS extend PFS after the next line of therapy in patients with recurrent or metastatic nasopharyngeal carcinoma.
PT-112 Treatment for Thymoma and Thymic Carcinoma Starts in a Phase 2 Study
April 18, 2022
Treatment with PT-112 has begun in a phase 2 study of patients with thymoma and thymic carcinoma.