EGFR Testing for Metastatic Non-Small Cell Lung Cancer with Jonathan W. Riess, MD, MS: Case 2

October 11, 2016

EGFR Testing for Metastatic Non-Small Cell Lung Cancer with Jonathan W. Riess, MD, MS


Riess case 2:

A 73-year-old woman with progressing EGFR+ adenocarcinoma.

  • A 73-year-old woman diagnosed with stage IV adenocarcinoma
  • Based on her EGFR+ status, she was treated with erlotinib
  • After 9 months her disease progressed, along with the presence of minor symptoms
  • Tissue biopsy was impeded by the tumor’s location; therefore, cell-free DNA testing was ordered
  • Based on the positive results for a T790M mutation, the patient was switched to osimertinib.
  • Her disease continues to be well-controlled on second-line therapy