Metastatic Lung Cancer with Jared M. Weiss, MD: Case 2

Weiss case 2:

A 62 year-old neversmoker with stage IV adenocarcinoma

• Mutation testing showed an EGFR exon 19 mutation
• The patient was treated with erlotinib for 1 year; he developed diarrhea and rash which was successfully managed
• After 3 months, his disease showed progression on CT; he remained without symptoms.
• He subsequently developed cough and shortness of breath, correlated to progression of a centrally located lung lesion on his follow up CT scan
• Repeat biopsy and molecular testing of the central lesion showed EGFR T790M-positivity
• He was switched to osimertinib therapy and achieved a partial response
• The patient reported dramatic improvement in his well-being