Metastatic Lung Cancer with Jared M. Weiss, MD: Case 2
Metastatic Lung Cancer with Jared M. Weiss, MD
Weiss case 2:
A 62 year-old neversmoker with stage IV adenocarcinoma
- Mutation testing showed an EGFR exon 19 mutation
- The patient was treated with erlotinib for 1 year; he developed diarrhea and rash which was successfully managed
- After 3 months, his disease showed progression on CT; he remained without symptoms.
- He subsequently developed cough and shortness of breath, correlated to progression of a centrally located lung lesion on his follow up CT scan
- Repeat biopsy and molecular testing of the central lesion showed EGFR T790M-positivity
- He was switched to osimertinib therapy and achieved a partial response
- The patient reported dramatic improvement in his well-being
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