Novel Strategies and Treatments in Chronic Lymphocytic Leukemia


John Allan, MD, speaks to the exciting future of treatments for chronic lymphocytic leukemia.

Case: A 70-Year-Old Woman with Newly Diagnosed Chronic Lymphocytic Leukemia

Initial Presentation:

  • A 70-year-old woman presented to her PCP for a routine checkup complaining of moderate, progressive fatigue and unintended weight loss over the last 4 months.
  • PMH: hypercholesterolemia (well controlled on medication; reports having a relatively healthy diet)
  • SH: Retired nurse; exercises at least 30 minutes per day most days of the week; enjoys spending time with her grandkids and traveling with her spouse; ~1-2 drinks in social settings per week
  • PE: vital signs WNL, right cervical lymphadenopathy~2.7 cm, spleen palpable 5 cm below costal margin, otherwise well-appearing
  • Laboratory findings:
    • WBC 186,000; 75% lymphocytes
    • Hb 9.4 g/dL
    • Platelets 85 X 109/L
  • Cr Cl: 61 ml/min
  • Flow cytometry; CD5+, CD19+, CD23+
  • beta2M, 3.8 mg/L
  • IGHV mutational status: unmutated; TP53 unmutated
  • ECOG PS 0
  • BM biopsy; diffuse infiltration by CLL


  • Options for treatment were reviewed and discussed with the patient, her spouse, and the care team.
  • The decision was made to initiate the patient on fixed duration venetoclax + obinutuzumab.
Related Videos
Video 8 - "Clinical Pearls for Optimal Management of mHSPC"
Video 7 - "Multidisciplinary Approach in mHSPC Management "
Video 6 - "Treatment Considerations in High Disease Burden and Comorbidities"
Video 5 - "Pivotal Trials in mHSPC"
Video 4 - "ARASENS Trial- Darolutamide in mHSPC"
Video 3 - "Treatment Intensification in Metastatic Prostate Cancer"
Video 2 - "Treatment Options for mHSPC"
Video 1 - "Initial Impression and Risk Assessment"
Related Content