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Commentary|Articles|December 11, 2014

Pembrolizumab for TNBC

Sara Hurvitz, MD, medical oncologist, UCLA Medical Center, discusses the results of a study looking at pembrolizumab (Keytruda) in patients with triple-negative breast cancer (TNBC).

Clinical Pearls

Sara Hurvitz, MD, medical oncologist, UCLA Medical Center, discusses the results of a study looking at pembrolizumab (Keytruda) in patients with triple-negative breast cancer (TNBC).

  • Inhibiting the PD-1 pathway showed activity in advanced TNBC in a previous phase I study.
  • In this study, a heavily pretreated population of patients with TNBC tolerated pembrolizumab well. Durable responses were observed.
  • There remains a need for breast cancer doctors to understand how to manage toxicities associated with immunotherapies.

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