Genitourinary Cancers

COVID-19 Presents an Opportunity for Precision Medicine to Play Expanded Role in Care

March 30, 2020

A sudden surge in the cases of COVID-19 due to pandemic, along with efforts to contain it, has led to multiple challenges that no country has experienced in the last several decades. The global pandemic from COVID-19 poses a unique set of challenges not only for patients with cancer who need their treatment, but also for caregivers, oncologists, and the overall care team.

Expert Expands on Evolving Treatment Strategies for Prostate and Urothelial Cancers

March 29, 2020

At the Annual Education Summit of the Medical Oncology Association of Southern California, Tanya Dorff, MD, discussed evolving practices in prostate and urothelial cancers as well as highlighted controversies in the treatment landscape such as the role of combination therapy in prostate cancer.

Liquid Biopsy Reveals Differences in DDR Genes in Prostate Cancer

March 27, 2020

Liquid biopsy results that identify DNA damage repair genes in prostate cancer may be a useful tool in clinical-deci­sion making, espe­cially because these genes can elucidate therapeutic vulnera­bilities that could be exploited by current treatments.

Delivering Optimal Outcomes in Prostate Cancer Despite Adverse Events

March 25, 2020

Eugene B. Cone, MD, discusses the strategies for treating patients with prostate cancer who develop adverse events, such as cardiac events and immune-related events.

A 75-Year-Old Man With Metastatic Castrate-Resistant Prostate Cancer

March 24, 2020

A 75-Year-Old Man With Metastatic Castrate-Resistant Prostate Cancer

Barriers Impact Receipt of Life-Extending Treatment in High-Risk Prostate Cancer for Younger Patients

March 24, 2020

A significant percentage of younger men with high-risk prostate cancer who display minimal comorbidities continue to receive nondefinitive therapy (NDT), despite research that has demonstrated local therapy is more beneficial in this patient population, according to findings from a study published in JAMA Oncology show. A number of reasons for this have been identified, including insurance status and race/ethnicity.

South Carolina Oncology Practice Continues Cautious Operation Amidst the COVID-19 Pandemic

March 23, 2020

In an interview with Targeted Oncology, Kashyap Patel, MD, discussed the COVID-19 pandemic and the implementation of new precautions in his practice as the number of COVID-19 infected persons rises in the state.

Enzalutamide Plus Standard Treatment May Extend Remission in High-Risk Recurrent Prostate Cancer

March 23, 2020

The addition of 6 months of oral daily enzalutamide to standard salvage radiation and hormone therapy is safe and may improve prostate cancer remission rates at 2 and 3 years postoperatively among patients with high-risk disease, according to a recent paper in European Urology Oncology.

Before Starting Targeted Therapy for Prostate Cancer, Determine Cardiovascular Risk

March 21, 2020

Elderly patients with advanced prostate cancer should be evaluated for preexisting cardiovascular diseases before taking oral androgen signaling inhibitors by a multidisciplinary team, includ­ing a cardiologist, according to a recent retro­spective study. Investigators at Thomas Jeffer­son University in Philadelphia, Pennsylvania, demonstrated that after receiving abiraterone acetate or enzalutamide, these patients had higher rates of short-term mortality than similar patients without CVDs.

Benefit of PARP Inhibitors May Extend to Certain Tumors With IDH Mutations

March 21, 2020

Patients harboring IDH1/2 muta­tions may receive benefit by the use of PARP inhibitors, with investigators initi­ating clinical trials in patients across multiple different tumor types to determine the efficacy of this strategy.