Arlene O. Siefker-Radtke, MD

Arlene O. Siefker-Radtke, MD, professor, department of genitourinary medical oncology, division of cancer medicine, The University of Texas MD Anderson Cancer Center, discusses the data seen with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) that targets TROP-2, which is expressed frequently in urothelial cancer cells.

Response rates were around 30% with this agent, but it was associated with toxicites, says Siefker-Radtke. However, toxicities are common with other ADCs, such as enfortumab vedotin, which has a higher rate of neutropenia and neutropenic fevers.

Videos

Arlene O. Siefker-Radtke, MD, discusses the data seen with sacituzumab govitecan, an antibody-drug conjugate that targets TROP-2, which is expressed frequently in urothelial cancer cells.

Using Sacituzumab Govitecan and Other ADCs in Urothelial Cancers

Arlene O. Siefker-Radtke, MD, professor of genitourinary medical oncology at MD Anderson Cancer Center, discusses the results presented at the 2018 ASCO Annual Meeting from a phase II cohort investigating erdafitinib in previously treated patients with urothelial cancer. Erdafitinib is a fibroblast growth factor receptor (FGFR) inhibitor that targets FGFR 1 through 4 and has previously shown promising activity.

This trial was designed to investigate options for a population that is in need of a new agent after previously receiving an immunotherapy or chemotherapy alone. Patients with previously treated metastatic urothelial tumors were randomized to receive erdafitinib in either intermittent or continuous dosing. Initial data supported the continuous dosing regimen.

Of 99 patients enrolled in a phase II cohort of continuous dosing at 9 mg of erdafitinib, there was a 40% objective response rate. The therapy was well tolerated with a low number of patients discontinuing due to treatment-related adverse events. The most common reason for discontinuation was progression of disease.

Arlene O. Siefker-Radtke, MD, professor of genitourinary medical oncology at MD Anderson Cancer Center, discusses the results presented at the 2018 ASCO Annual Meeting from a phase II cohort investigating erdafitinib in previously treated patients with urothelial cancer. Erdafitinib is a fibroblast growth factor receptor (FGFR) inhibitor that targets FGFR 1 through 4 and has previously shown promising activity.&nbsp;

Discussion on Trial Investigating Erdafitinib in Patients With Urothelial Cancer

Arlene O. Siefker-Radtke, MD, associate professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the pairing of neoadjuvant chemotherapy and surgery in patients with bladder cancer. Siefker-Radtke says her preferred mathod of neoadjuvant chemotherapy is doxorubicin plus ifosfamide with an alternating regimen of etoposide cisplatin.

Siefker-Radtke says her preferred mathod of neoadjuvant chemotherapy is doxorubicin plus ifosfamide with an alternating regimen of etoposide cisplatin.

Arlene O. Siefker-Radtke, MD | Authors

Articles

Using Sacituzumab Govitecan and Other ADCs in Urothelial Cancers

Discussion on Trial Investigating Erdafitinib in Patients With Urothelial Cancer

Dr. Arlene O. Siefker-Radtke on Neoadjuvant Chemotherapy Plus Surgery in Bladder Cancer