Olaparib Demonstrates Significant PFS Benefit in Phase III mCRPC TrialAugust 7th 2019
Olaparib demonstrated a statistically significant improvement in radiographic progression-free survival compared with enzalutamide or abiraterone acetate in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair mutation and have progressed on prior treatment with new hormonal anticancer treatments, according to early findings from the PROfound trial.
Key Takeaways from KEYNOTE-365 in Metastatic Castration-Resistant Prostate CancerJuly 18th 2019
Evan Y. Yu, MD, discussed the key takeaways from the phase Ib/II KEYNOTE-365 trial, which evaluated different novel pembrolizumab (Keytruda) combinations in patients with metastatic castration-resistant prostate cancer.
Improved Overall Survival in mHSPC With Enzalutamide Plus Standard of CareJuly 18th 2019
Testosterone suppression with docetaxel, the standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC), was combined with chemotherapy or enzalutamide (Xtandi) to assess the potential improvement in overall survival compared with non-steroidal anti-androgens like bicalutamide, nilutamide, and flutamide in the phase III ENZAMET trial. <br />
Achieving MFS and Improved Quality of Life in nmCRPC With DarolutamideJuly 16th 2019
Karim Fizazi, MD, PhD,head of the Department of Cancer Medicine, Institut Gustave Roussy, University of Paris-Sud, gives highlights on the updated findings from the phase III ARAMIS trial using darolutamide for the treatment of patients with nonmetastatic castration-resistant prostate cancer, recently presented during the 2019 ASCO Annual Meeting. <br />
Clinical Findings Identify Associations Between Genomic Correlates and Outcomes in Metastatic CRPCJuly 12th 2019
A study aimed at exploring genomic diversity and defining its associations with clinical outcomes in metastatic castration-resistant prostate cancer found that alterations in RB1 were a potent predictor of poor survival and that other common aberrations may serve as prognostic indicators of treatment response, according to recent work published in the Proceedings of the National Academy of Sciences.
Apalutamide Leads to MFS Risk Reduction for Nonmetastatic CRPCJuly 2nd 2019
In a posthoc analysis of the phase III SPARTAN trial, lead investigator Julie N. Graff, MD, and colleagues examined the study’s apalutamide (Erleada) arm to determine whether the agent affected metastasis-free survival (MFS), time to metastasis (TTM), and location of metastasis as a function of prostate-specific antigen (PSA) nadir.
Treatment Patterns at End of Life Explored in Large, National DatabaseJune 20th 2019
The American Cancer Society, Dana-Farber Cancer Institute, Baptist Cancer Center, and the Mayo Clinic report that treatment patterns varied markedly by cancer type and care facility setting for patients with de novo metastatic disease who died within 1 month after diagnosis, based on an analysis of data from 100,848 patients collected from the National Cancer Database, a hospital-based cancer registry that captures 70% of patients in the United States with a new diagnosis.