Melanoma | Clinical

Dendritic Cell Vaccine Shows Long-Term Survival Benefit in High-Risk Melanoma

August 06, 2020

The final data of a personalized tumor lysate, particle-loaded, dendritic cell vaccine demonstrated that patients with stage III or IV melanoma with high-risk of recurrence after complete surgical resection had better survival benefit and disease-free survival rate with the vaccine over placebo, according to a press release from Elios Therapeutics.

Chipping Away at the Surface of Melanoma Treatment: Narrowing Down Therapies

July 26, 2020

A guideline from the American Society of Clinical Oncology addresses 4 clinical questions regarding approaches to systemic treatment for different types and stages of melanoma, in addition to summarizing the trials on which the recommendations were based.

Pembrolizumab Shows Long-Term Benefit in Advanced Melanoma Subgroups

July 17, 2020

A retrospective 10-year analysis of 3 randomized clinical trials explored the question of whether BRAF V600E/K mutations or previous use of a BRAF inhibitor with or without a MEK inhibitor in patients with metastatic disease impacted patient response to pembrolizumab.

Dabrafenib Plus Trametinib Demonstrates Benefit in BRAF-Mutant Melanoma

June 23, 2020

Axel Hauschild, MD, PhD, discusses the key findings from the phase 3 COMBI-AD clinical trial, which demonstrated sustained long-term relapse-free survival benefit with the combination of dabrafenib and trametinib compared with placebo in patients with resected, stage III BRAF V600E/K-mutated melanoma.