Study Demonstrates Feasibility and Tolerability of 45 Gy Novel Radiotherapy in CNS Cancers
In an interview with Targeted Oncology, Rupesh Kotecha, MD, discussed research around the use of pulse reduced dose rate intensity-modulated radiotherapy in patients with central nervous system malignancies.
Wearable Patient-Tracking Device to Inform Time and Delivery of Radiotherapy
Alonso Gutierrez, MD, discusses the initial results from a feasibility study which evaluated the use of a daily wearable patient-tracking device to optimize radiation machine use and time the delivery of treatment.
Study Shows H-RT Is Safe, Effective for Low-Risk Prostate Cancer
Study results that examined patient-reported outcomes and quality of life measures demonstrate that hypofractionated radiotherapy (H-RT) is a viable, safe, and value-added alternative to patients with low-risk prostate cancer.
The Potential Roles of Immunotherapy in NSCLC Treatment
Puneeth Iyengar, MD, PhD, radiation oncologist, University of Texas Southwestern Medical Center, discusses the two potential roles immunotherapy could play in the treatment of NSCLC.
Low-Risk Meningioma Study Adds Clarity to Irradiation Role
Patients with low-risk meningioma had a 3-year progression-free survival (PFS) that modestly exceeded expectations after gross total resection followed by observation, results of a cooperative group trial showed.
Findings of a Study Comparing Standard Radiation to IMRT in Endometrial, Cervical Cancer
Ann H. Klopp, MD, PhD, discusses the results of a recent trial comparing standard radiation to intensity-modulated radiation therapy (IMRT) in endometrial and cervical cancer, and what impact these results will have.
Computer Simulation Helps Plan Transducer Placement in Glioblastoma
For patients who are likely to experience contiguous recurrence of glioblastoma, a new computer simulation using tumor treating fields (TTF) and employing a personalized transducer array, delivered electric field (EF) intensities that exceeded therapeutic intensities in 3 different tumor locations.
High Rates of Overall Survival Show Benefit of SBRT in Unresectable Liver Cancer
Results from a phase II study from Korea demonstrated high rates of tumor local control, overall survival (OS), and grade 1/2 gastrointestinal and hepatic toxicities in patients who received stereotactic body radiotherapy (SBRT) for unresectable hepatocellular carcinoma (HCC) after incomplete transarterial chemoembolization (TACE).
Radiation-TGFβ Inhibition Combo Elicits Activity in Metastatic Breast Cancer
A strategy to stimulate an immune response in radiation-damaged tumor cells resulted in preliminary evidence of activity—including longer survival—in a small clinical trial of patients with metastatic breast cancer.
KRAS-Variant HNSCC Outcomes May Improve With Cetuximab
Patients with head and neck cancer whose disease is associated with <em>KRAS</em> variant had significantly better progression-free survival (PFS) and overall survival (OS) when treated with the monoclonal antibody cetuximab (Erbitux), according to findings of a retrospective analysis of a randomized trial.
Concurrent Chemoradiation, Radical Cystectomy Demonstrate Similar Median OS Rates in Urothelial Cancer
Jim Zhong, MD, and colleagues describe a National Cancer Database (NCDB) outcomes analysis of patients with muscle invasive bladder cancer treated with either radical surgery or bladder preservation therapy.
No Benefit from Combined Irradiation in Intermediate-Risk Prostate Cancer
The addition of external-beam radiotherapy (EBRT) to interstitial brachytherapy failed to reduce prostate cancer progression compared to brachytherapy alone in men with intermediate-risk disease, interim data from a randomized trial showed.
Study Results Show Chemoradiation Significantly Improves PFS in Follicular Lymphoma
According to findings from a multicenter randomized trial, chemoradiation for early-stage, low-grade follicular lymphoma led to significant improvement in progression-free survival (PFS) compared with involved-field radiotherapy alone (IFRT).
Enhanced Immune Response Seen With Ipilimumab Plus Radiation in Melanoma
Pro-inflammatory cytokines were elevated in patients with melanoma undergoing the combination treatment of radiation therapy and the systemic anti�CTLA-4 immunotherapy, ipilimumab.
Long-Term Study Reports RT Plus Anti-Androgen Improves Prostate Cancer Survival
Patients who had prostate cancer recurrence after radical prostatectomy lived significantly longer with the addition of hormonal therapy to salvage radiotherapy, long-term follow-up from a randomized trial showed.
Trend Toward Less Bowel Toxicity for IMRT Versus 3-D Conformal RT in Cervical Cancer
Intensity-modulated radiation therapy (IMRT) for cervical cancer has led to a double-digit decrease in late bowel toxicity compared with 3-D conformal radiation therapy without statistical significance.
Brief RT for Early Prostate Cancer Gets High Marks in Preliminary Trial
Ultra-hypofractionated radiation therapy for low-risk prostate cancer led to significantly lower rates of bowel and urinary dysfunction compared with patients treated with conventional radiotherapy regimens.
Dr. Erin Murphy Talks About Treatments For Young Ependymoma Patients
Dr. Erin Murphy talks about a study presented by Dr. Thomas E. Merchant regarding young patients with ependymoma and how they can be treated effectively with a regiment of adjuvant radiation.
Prostate Cancer Study Shows Hypofractionation Comparable to Standard Radiation in Low-risk Patients
Hypofractionated radiotherapy can achieve similar cure rates with similar side effects compared with conventional radiotherapy for men with low-risk, early prostate cancer, according to a recent study.
Shorter Radiation Technique Comparable to Standard Radiation for Low-Risk Breast Cancer
A phase III study shows noninferiority of accelerated partial breast irradiation as compared to conventional whole breast irradiation.
Dr. Minesh Mehta Talks About A Newly-Approved Device To Treat Glioblastoma
Minesh Mehta, MBChB, talks about the recently FDA-approved Optune used to treat newly diagnosed glioblastoma. The device utilizes alternating electric fields to inhibit tumor cell growth.
Long-term Outcomes Comparable Between Conventional vs Hypofractionated Radiation Therapy in Prostate Cancer
Patients who received hypofractionated radiation therapy did not demonstrate statistically significant differences in long-term outcomes compared with patients who received conventional radiation therapy, according to a study .
Dr. Jay Ciezki Talks About the Benefits of Stereotactic Body Radiation Therapy
Jay Ciezki, MD, staff member of the Department of Radiation Oncology at Cleveland Clinic and Department of Cell Biology at Cleveland Clinic, talks about the potential advantages of utilizing Stereotactic Body Radiation Therapy in prostate cancer patients.
Hypofractionated Radiotherapy May be Viable in Intermediate- and High-Risk Prostate Cancer
Hypofractionation, known as delivering higher doses of radiation in fewer fractions, appears to be feasible and non-inferior compared with conventional fractionated radiotherapy.
Dexamethasone Reduces Radiotherapy-Related Bone Pain Flare
Flares of bone pain decreased significantly when the oral corticosteroid dexamethasone was added to radiation therapy in patients with metastatic cancer, according to a randomized, placebo-controlled trial.
Coordination of Care Based on Patient-Reported Outcomes Improves End-of-Life Care and Lowers Costs
Coordinating radiation therapy teams and palliative care teams based on patient reported outcomes from University of Virginia Health System improved outpatient symptom management and decreased end-of-life hospitalizations, as well as costs of care for patients with late-stage cancer.
Low-Risk Stage IV NSCLC Patients Achieve Long-Term Survival After Aggressive Treatment
Timing of metastatic development, lymph node involvement, and type of disease all factor into the overall survival (OS) rate of patients with stage IV NSCLC, and could offer a potential risk stratification scheme for ablative therapy.
Chemo/SABR Combo May Allow Patients With Advanced Pancreatic Cancer to Undergo Surgery
The combination of chemotherapy and stereotactic ablative radiotherapy (SABR) may allow patients with locally advanced pancreatic cancer to undergo surgery, a procedure that might not have otherwise been an option.
MRI-Guided Radiotherapy Reduces Sexual Dysfunction in Prostate Cancer
With the use of MRI imaging to restrict doses to erectile tissues, nearly half of men treated with EBRT for prostate cancer were able to be sexually active without aids or medications 5 years later, and nearly 80% could be sexually active if such support was an option.
Abbreviated Course of ADT + RT Produces Similar Outcomes, Improves QoL in High-Risk Prostate Cancer
When given along with radiation therapy to men with high-risk prostate cancer, 18 months of androgen-deprivation therapy (ADT)â€”as opposed to a 36-month courseâ€”not only generates similar long-term outcomes, but results in a better quality of life.
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