High Levels of KRAS in ctDNA of Pancreatic Cancer May Mean Lower OS
During a retrospective study of 182 patients with nonresectable pancreatic cancer, a negative association was found between baseline circulating tumor (ct)DNA KRAS counts in plasma and overall survival (OS), which indicates that patients with lower KRAS burden in ctDNA survive longer.
Biomarker Analysis of GIST Tumors Suggests New Potential for Old Treatments
Researchers for Caris Life Sciences have used the company's proprietary tumor profiling platform to identify biomarkers in GIST that may be used to identify more effective therapeutic regimens for individuals with TKI-resistant GIST.
Potential Predictive and Prognostic Biomarkers for Ziv-Aflibercept Treatment Identified
Interim results reported from a retrospective study of plasma samples from the VELOUR trial reveal multiple potential prognostic and predictive biomarkers to guide treatment of patients with mCRC with the VEGF-inhibitor ziv-aflibercept.
Treatment With a Monocyte-Targeting Agent for Pancreatic Cancer
Andrea Wang-Gillam, MD, PhD, discusses a trial looking at PF-04136309, an investigational chemokine receptor antagonist, in combination with FOLFIRINOX for the treatment of locally advanced pancreatic cancer.
Monocyte-Targeting Agent Elicits Responses in Locally Advanced Pancreatic Cancer
Almost half of patients with borderline resectable or locally advanced pancreatic cancer had objective responses to treatment with PF-04136309, an investigational chemokine receptor antagonist.
Lanreotide Improves PFS in Pancreatic NET Subgroup
Lanreotide (Somatuline Depot) improved progression-free survival and resulted in more disease control compared with an observation strategy among patients with pancreatic neuroendocrine tumors (pNETs).
Ramucirumab Improves Survival in HCC Patients With Elevated AFP
An analysis of patients with advanced hepatocellular carcinom and elevated Î±-fetoprotein who received second-line ramucirumab showed a significant improvement in overall survival.
MM-398 Benefit Further Supported in Metastatic Pancreatic Cancer
An analysis of the per-protocol population in the phase III NAPOLI-1 trial supports the benefits of adding MM-398 to 5-fluorouracil plus leucovorin (5-FU/LV) for the treatment of metastatic pancreatic cancer.
Polymorphisms May Predict Improved Outcomes With Sorafenib in HCC
Two polymorphisms of a vasodilatory enzyme had significant associations with improved survival in liver cancer treated with an inhibitor of vascular endothelial growth factor receptor (VEGFR).
Less Intense Gemcitabine/Nab-Paclitaxel Schedule Reduces Side Effects in Pancreatic Cancer
Changing the administration schedule for gemcitabine plus nab-paclitaxel (Abraxane) from weekly to every other week significantly reduced side effects without impacting efficacy as a frontline treatment for patients with metastatic pancreatic cancer.
MET Inhibitor AMG-337 Shows Promise in Some Patients with Advanced Gastroesophageal Cancer
Patients with advanced, MET-amplified gastroesophageal cancer had a high likelihood of response to an investigational MET inhibitor, results from a preliminary, dose-escalation trial suggested.
Pembrolizumab Demonstrates Activity in Gastric Cancer in KEYNOTE-012
Pembrolizumab showed promising antitumor activity and a manageable toxicity profile in patients with metastatic gastric cancer, according to updated findings from the KEYNOTE-012 study.
Classifying and Predicting Response in NETs
Pamela L. Kunz, MD, discusses classifying neuroendocrine tumors (NETs) and the potential to predict response.
'Watch and Wait' Approach May Lead to Excellent Outcomes in Rectal Cancer
A â€œwatch and waitâ€ surveillance approach may allow certain patients with rectal cancer to achieve excellent outcomes without immediate surgery. This retrospective review of clinical data was presented at the 2015 Gastrointestinal Cancers Symposium.
FOLFOXIRI Plus Bevacizumab Superior to FOLFIRI in mCRC
Intensifying the chemotherapy component of a standard first-line bevacizumab-containing regimen reduced the risk of death by about 20% and doubled the 5-year overall survival (OS) rate among patients with mCRC.
Vitamin D Improves Outcomes in Patients With mCRC
Patients with newly diagnosed metastatic colorectal cancer (mCRC) who had higher levels of vitamin D in their blood lived a median of 8 months longer and experienced greater disease-free survival after their cancer treatment. This research was reported at a press briefing in advance of the 2015 Gastrointestinal Cancers Symposium.
Second-Line Ramucirumab Extends OS in Phase III mCRC Trial
Second-line treatment with the VEGFR2 inhibitor ramucirumab (Cyramza) combined with standard FOLFIRI extended survival by 1.6 months versus FOLFIRI alone in patients with metastatic colorectal cancer (mCRC).
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