Endocrine Society Annual Meeting | Conferences

PARP-1 Has Role in Estrogen-Related Transcription

March 09, 2015

Poly (ADP-ribose) polymerase-1 (PARP-1) is a multifunctional, chromatin-regulating protein. PARP inhibitors are currently undergoing clinical trials as potential targeted therapies for the treatment of breast, uterine, colorectal, and ovarian cancer.

AR-V7 in Prostate Cancer Cells Introduces Potential Therapeutic Target for CRPC

March 09, 2015

A recent study showed that the androgen receptor (AR) splice variant AR-V7 activated full-length AR through an alternative biosynthesis pathway and increased citrate utilization through altered metabolic activities, which may partially explain its resistance to conventional androgen deprivation therapy (ADT).