The Phase 3 CABINET Trial: Cabozantinib in Advanced Neuroendocrine Tumors
Thorvardur R. Halfdanarson, MD, discusses how neuroendocrine tumors are classified according to World Health Organization guidelines, diagnosed primarily through imaging, and treated with approaches including observation, surgery, somatostatin analogues, chemotherapy, peptide receptor radionuclide therapy, and the newly approved cabozantinib, with treatment decisions based on tumor grade, disease extent, and symptom presence.
EP. 1: Overview of Neuroendocrine Tumors
May 14th 2025A panelist discusses how neuroendocrine tumors are defined by World Health Organization (WHO) classification, graded based on Ki-67 proliferative index, diagnosed through imaging (often incidentally), and most commonly found in the small bowel, lungs, and pancreas.
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EP. 2: Treatment Options for Patients with Neuroendocrine Tumors
May 14th 2025A panelist discusses how first-line treatment options for neuroendocrine tumors depend on tumor grade, disease extent, and symptoms, ranging from observation for asymptomatic cases to somatostatin analogues, chemotherapy, and the newly approved cabozantinib.
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EP. 3: CABINET Trial: Study Design and Patient Population
May 21st 2025A panelist discusses how the CABINET trial was a National Cancer Institute (NCI)–supported study conducted by the Alliance for Clinical Trials in Oncology that enrolled patients with well-differentiated grade 1 through 3 pancreatic or extrapancreatic neuroendocrine tumors who had progressed after somatostatin analogue therapy and at least 1 other FDA-approved therapy.
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A panelist discusses how the CABINET trial showed significant progression-free survival benefits for cabozantinib compared with placebo (particularly in pancreatic neuroendocrine tumors (NETs), why progression-free survival (PFS) is a meaningful end point for NETs, and that safety findings revealed familiar adverse effects requiring dose reductions in about two-thirds of patients.
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