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Opinion|Videos|March 13, 2025

AE Management With TKIs and Belzutifan

Author(s)Sumanta Kumar Pal, MD

A panelist discusses how managing adverse events associated with TKIs and belzutifan requires a proactive approach encompassing prevention strategies, regular monitoring, dose modifications when needed (particularly for combination regimens), and evidence-based mitigation techniques, while considering the distinct toxicity profiles of each agent and the impact of dose adjustments on treatment efficacy.

Episodes in this series

1 KOL is featured in this series.

EP. 1 Patient With Favorable-Risk mRCC and Goals of Therapy

1 KOL is featured in this series.

EP. 2 Second-Line Therapy Options

1 KOL is featured in this series.

EP. 3 Lessons from TiNivo-2 and CONTACT-03

1 KOL is featured in this series.

EP. 4 Understanding Patient-Reported Outcomes in RCC

1 KOL is featured in this series.

EP. 5 Case (cont.): Dr Pal’s Approach Toward 2L Therapy Selection

1 KOL is featured in this series.

EP. 6 Sequencing Through Multiple Lines of Therapy for mRCC

1 KOL is featured in this series.

EP. 7 AE Management With TKIs and Belzutifan

1 KOL is featured in this series.

EP. 8 Potentially Groundbreaking Research in RCC

Video content above is prompted by the following:

What advice can you offer to community oncologists with respect to management of AEs associated with TKIs or belzutifan?
How do the toxicities of TKIs compare with those of belzutifan?
How do you prevent, monitor, mitigate, and manage treatment-associated toxicities?
How do you handle dose modifications
For tivozanib
Other options (eg, len/eve)
How do you decide which drug to modify when using a combination regimen?
What is the data on efficacy of these therapies with reduced dosages

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