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Opinion|Videos|December 19, 2025

ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

Author(s)Laura Huppert, MD

Episodes in this series

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 2 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

EP. 2 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

EP. 3 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

EP. 3 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

Updated safety from the ASCENT-03 and ASCENT-04 trials were shared at the 2025 San Antonio Breast Cancer Symposium (SABCS). Both studies explored sacituzumab govitecan in the first-line setting for patients with triple-negative breast cancer, with ASCENT-03 exploring the ADC as a monotherapy and ASCENT-04 evaluating the ADC in combination with the PD-1 inhibitor pembrolizumab. In this video, Laura Huppert, MD, highlights the safety outcomes from the trials presented at SABCS 2025 and shares her expertise on managing adverse events associated with these treatments.

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