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Opinion|Videos|January 6, 2026

ASCENT-04: Outcomes With Sacituzumab Govitecan Plus Pembrolizumab In First-Line TNBC

Author(s)Laura Huppert, MD

Episodes in this series

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 2 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

EP. 2 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

EP. 3 ASCENT-04: Outcomes With Sacituzumab Govitecan Plus Pembrolizumab In First-Line TNBC

EP. 3 ASCENT-04: Outcomes With Sacituzumab Govitecan Plus Pembrolizumab In First-Line TNBC

EP. 4 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

EP. 4 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

Laura Huppert, MD, discusses efficacy and safety outcomes from the phase 3 ASCENT-04 trial, which compared the combination of the antibody-drug conjugate sacituzumab govitecan plus thePD-1 inhibitor pembrolizumab with the standard regimen of pembrolizumab plus chemotherapy in the first-line setting for patients with PD-L1–positive advanced triple-negative breast cancer (TNBC). She also explains the clinical implications of the results on the TNBC treatment paradigm.

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